Publications

81. A Concise Synthesis of Pleurotin Enabled by a Nontraditional C–H Epimerization

Hoskin, J. F.; Sorensen, E. J. J. Am. Chem. Soc. 2022, 144, 14042–14046.

80. A C−H Functionalization Strategy Enables an Enantioselective Formal Synthesis of (−)-Aflatoxin B₂

Falcone, N. A.; Bosse, A. T.; Park, H.; Yu, J.-Q.; Davies, H. M. L.; Sorensen, E. J. Org. Lett. 2021, 23, 9393–9397.

79. Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp³)‒H Arylation with a Transient Directing Group

Provencher, P. A.; Hoskin, J. F.; Wong, J. J.; Chen, X.; Yu, J.-Q.; Houk, K. N.; Sorensen, E. J. J. Am. Chem. Soc. 2021, 143, 20035–20041.

78. Cyclization by C(sp³)–H Arylation with a Transient Directing Group for the Diastereoselective Preparation of Indanes

Provencher, P. A.; Bay, K. L.; Hoskin, J. F.; Houk, K. N.; Yu, J.-Q.; Sorensen, E. J. ACS Catal. 2021, 11, 3115–3127.

77. Donor–Acceptor–Acceptor 1,3-Bisdiazo Compounds: An Exploration of Synthesis and Stepwise Reactivity

Abrams, D. J.; Davies, H. M. L.; Sorensen, E. J. Org. Lett. 2020, 22, 1791-1795.

76. Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

Balaguer, F.A.; Mühlethaler, T.; Estévez-Gallego, J.; Calvo, E.; Giménez-Abián, J.F.; Risinger, A.L.; Sorensen, E.J.; Vanderwal, C.D.; Altmann, K.-H.; Mooberry, S.L.; Steinmetz, M.O.; Oliva, M.Á.; Prota, A.E.; Díaz, J.F. Int. J. Mol. Sci. 2019, 20, 1392.

75. Synthesis of (+)-Lineariifolianone and Related Cyclopropenone-Containing Sesquiterpenoids

Reber, K. P.*; Gilbert, I. W.; Strassfeld, D. A.; Sorensen, E. J. J. Org. Chem. 2019, 84, 5524-5534.

74. Recent Applications of C–H Functionalization in Complex Natural Product Synthesis

Abrams, D. J.^‡; Provencher, P. A.^‡; Sorensen, E. J. Chem. Soc. Rev. 2018, 47, 8925-8967.

73. Ir(III)-catalyzed Ortho C–H Alkylations of (Hetero)aromatic Aldehydes Using Alkyl Boron Reagents

Chen, X.-Y.; Sorensen, E. J. Chem. Sci. 2018, 9, 8951-8956.

72. Rhodium-Catalyzed C–H Amination: A Case Study of Selectivity in C–H Functionalization Reactions

Mack, J. B. C.; Bedell, T. A.; DeLuca, R. J.; Hone, G. A. B.; Roizen, J. L.; Cox, C. T.; Sorensen, E. J.; Du Bois, J. J. Chem. Educ. 2018, 95, 2243–2248.

71. Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse D-Tyr Analogs

Ozturk, S.; Forneris, C. C.; Nguy, A. K. L.; Sorensen, E. J.; Seyedsayamdost, M. R. J. Org. Chem. (Part of special issue: “Synthesis of Antibiotics and Related Molecules”) 2018, 83, 7309-7317.

70. Installation of Multiple Aryl Ether Crosslinks onto Non-native Substrate Peptides by the Vancomycin OxyB

Forneris, C. C.¹; Ozturk, S.¹; Sorensen, E. J.; Seyedsayamdost, M. R. Tetrahedron (Prof. Herzon’s Tetrahedron Young Investigator Award Special Issue) 2018, 74, 3231-3237.

69. Pd-catalyzed, ortho C-H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups

Chen, X.-Y.; Sorensen, E.J. J. Am. Chem. Soc. 2018, 140, 2789-2792.

68. Pd-Catalyzed Ortho C–H Hydroxylation of Benzaldehydes Using a Transient Directing Group

Chen, X.-Y.; Ozturk, S.; Sorensen, E.J. Org. Lett. 2017, 19, 6280-6283.

67. In Vitro Reconstitution of OxyA Enzymatic Activity Clarifies Late Steps in Vancomycin Biosynthesis

Clarissa C. Forneris, Seyma Ozturk, Marcus I. Gibson, Erik J. Sorensen, and Mohammad R. Seyedsayamdost ACS Chemical Biology 2017, 12, 2248-2253.

66. A Stereocontrolled Annulation of the Taccalonolide Epoxy Lactone onto the Molecular Framework of trans-Androsterone

Danielsson, J.; Sun, D.X.; Chen, X.-Y.; Risinger, A.L.; Mooberry, S.L.; Sorensen, E.J. Org. Lett. 2017, 19, 4892-4895.

65. Development of a Bio-Inspired Dual Catalytic System for Alkane Dehydrogenation

West, J.G.; Sorensen, E.J. Isr. J. Chem. 2017, 57, 259.

64. Synthesis of Fluorenones from Benzaldehydes and Aryl Iodides: Dual C–H Functionalizations Using a Transient Directing Group

Chen, X.-Y.; Ozturk, S.; Sorensen, E.J. Org. Lett. 2017, 19, 1140-1143.

63. Toward a Mild Dehydroformylation Using Base-Metal Catalysis

Abrams, D.J.; West, J.G.; Sorensen, E.J. Chem. Sci. 2017, 8, 1954.

62. The Uranyl Cation as a Visible-Light Photocatalyst for C(sp3)−H Fluorination

West, J.G.; Bedell, T.A.; Sorensen, E.J. Angew. Chem. Int. Ed. 2016, 55, 8923.

61. A Rapid Construction of a Benzo-Fused Indoxamycin Core Enabled by Site-Selective C-H Functionalizations

Bedell, T.A.; Hone, G.A.B.; Valette, D.; Yu, J.-Q.; Davies, H.M.L.; Sorensen, E.J. Angew. Chem. Int. Ed. 2016, 55, 8270–8274.

60. Diastereoselective Syntheses of Substituted Cis-Hydrindanones Featuring Sequential Inter- and Intramolecular Michael Reactions

Liu, J.; Marsini, M.A.; Bedell, T.A.; Reider, P.J.; Sorensen, E.J. Tetrahedron (Tetrahedron Young Investigator Award 2016 New Reactions and Methods and Their Applications to Complex Molecule Synthesis Neil K. Garg) 2016, 72, 3713-3717.

59. The Diels-Alder Cycloaddition Reaction in the Context of Domino Processes

West, J.G.; Sorensen, E.J. Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015) 2; pp 1-46.

58. Design and Synthesis of Molecular Scaffolds with Anti-infective Activity

Liu, J.; Bedell, T.A.; West, J.G.; Sorensen, E.J. Tetrahedron 2016, 72, 3579-3592.

57. Acceptorless Dehydrogenation of Small Molecules Through Cooperative Base Metal Catalysis

Julian G. West, David Huang & Erik J. Sorensen Nat. Commun. 2015, 6, 10093.

56. Biomimetic Total Synthesis of Gracilioethers B and C

Norris, M. D.; Perkins, M. V.; Sorensen, E. J. Org. Lett. 2015, 17, 668-671.

55. An Expedient Synthesis of Maraviroc (UK-427-857) via C-H Functionalization

Bedell, T. A.; Hone, G. A. B.; Du Bois, J.; Sorensen, E. J. Tetrahedron Letters (Memorial Symposium-in-print for Harry Wasserman) 2015, 56, 3620-3623.

54. Tandem Diels–Alder and Retro-Ene Reactions of 1-Sulfenyl- and 1-Sulfonyl-1,3-dienes as a Traceless Route to Cyclohexenes

Choi, J.; Park, C.; Yoo, H. J.; Kim, S.; Sorensen, E. J.; Chulbom, L. J. Am. Chem. Soc. 2014, 136, 9918–9921.

53. An Enantiospecific Synthesis of Jiadifenolide

Siler, D. A.; Mighion, J. D.; Sorensen, E. J. Angew. Chem. Int. Ed. 2014, 53, 5332-5335.

52. Toward a Synthesis of Hirsutellone B by the Concept of Double Cyclization

Reber, K. P.; Tilley, S. D.; Carson, C. A.; Sorensen, E. J. J. Org. Chem. 2013, 78, 9584-9607.

51. Taking risks in complex synthesis design

Sorensen, E. J.; Siler, D. A.; Mighion, J. D. Strategies and Tactics in Organic Synthesis. Ed. Michael Harmata, 2013. 249-273.

50. Organic Synthesis: A Biochemical Messenger Made Easily

Sorensen, E. J. Nature 2012, 489, 214-215.

49. A Chemical Synthesis of 11-methoxy Mitragynine Pseudoindoxyl Featuring the Interrupted Ugi Reaction

Kim, J.; Schneekloth, J. S.; Sorensen, E. J. Chem. Sci. 2012, 3, 2849-2852.

48. Concise, Stereocontrolled Synthesis of the Citrinadin B Core Architecture

Guerrero, C. A.; Sorensen, E. J. Org. Lett. 2011, 13, 5164-5167.

47. The catalytic asymmetric Diels-Alder reactions and post-cycloaddition reductive transpositions of 1-hydrazinodienes

Xie, H.; Sammis, G. M.; Flamme, E. M.; Kraml, C. M.; Sorensen, E. J. Chem. Eur. J. 2011, 17, 11131-11134.

46. Expanding the Pleuromutilin Class of Antibiotics by de novo Chemical Synthesis

Lotesta, S. D.; Liu, J.; Yates, E. V.; Krieger, I.; Sacchettini, J. C.; Freundlich, J. S.; Sorensen, E. J. Chem. Sci. 2011, 2, 1258-1261.

45. A Concise Synthesis of the Molecular Framework of Pleuromutilin

Liu, J.; Lotesta, S. D.; Sorensen, E. J. Chem. Commun. 2011, 47, 1500-1502.

44. A Concise and Convergent Synthesis of PA-824

Marsini, M. A.; Reider, P. J.; Sorensen, E. J. J. Org. Chem. 2010, 75, 7479-7482.

43. The Abyssomicin C Family as in vitro Inhibitors of Mycobacterium tuberculosis

Freundlich, J. S.; Lalgondar, M.; Wei, J. R.; Swanson, S.; Sorensen, E. J.; Rubin, E. J.; Sacchettini, J. C. Tuberculosis 2010, 90, 298-300.

42. Synthesis Enables a Structural Revision of the Mycobacterium tuberculosis-produced Diterpene Edaxadiene

Spangler, J. E.; Carson, C. A.; Sorensen, E. J. Chem. Sci. 2010, 1, 202-205.

41. Seebach’s Conjunctive Reagent Enables Double Cyclizations

Chandler, B. D.; Roland, J. T.; Li, Y.; Sorensen, E. J. Org. Lett. 2010, 12, 2746-2749.

40. A Hypervalent Iodine-Induced Double Annulation Enables a Concise Synthesis of the Pentacyclic Core Structure of the Cortistatins

Frie, J. L.; Jeffrey, C. J.; Sorensen, E. J. Org. Lett. 2009, 11, 5394-5397.

39. Bond Formations by Intermolecular and Intramolecular Trappings of Acylketenes and their Applications in Natural Product Synthesis

Reber, K. P.; Tilley, S. D.; Sorensen, E. J. Chem. Soc. Rev. 2009, 38, 3022-3034.

38. A Nature-Inspired Diels-Alder Reaction Facilitates Construction of the Bicyclo[2.2.2]octane Core of Andibenin B

Spangler, J. E.; Sorensen, E. J. Tetrahedron 2009, 65, 6739-6745.

37. A Rapid, Asymmetric Synthesis of the Decahydrofluorene Core of the Hirsutellones

Tilley, S. D.; Reber, K. P.; Sorensen, E. J. Org. Lett. 2009, 11, 701-703.

36. An Interrupted Ugi Reaction Enables the Preparation of Substituted Indoxyls and Aminoindoles

Schneekloth, J. S.; Kim, J.; Sorensen, E. J. Tetrahedron 2009, 65, 3096-3101.

35. A Synthesis of the Tricyclic Core Structure of FR901483 Featuring an Ugi Four-Component Coupling and a Remarkably Selective Elimination Reaction

Seike, H.; Sorensen, E. J. Synlett 2008, 5, 695-701.

34. Mechanistic and Structural Requirements for Active Site Labeling of Phosphoglycerate Mutase by Spiroepoxidates

Evans, M. J.; Morris, G. M.; Wu, J.; Olson, A. J.; Sorensen, E. J.; Cravatt, B. F. Mol. Biosyst. 2007, 3, 495-506.

33. Classical Carbonyl Reactivity Enables a Short Synthesis of the Core Structure of Acutumine

Moreau, R. J.; Sorensen, E. J. Tetrahedron 2007, 63, 6446-6453.

32. Cyclostreptin Binds Covalently to Microtubule Pores and Lumenal Taxoid Binding Sites.

Buey, R. M.; Calvo, E.; Barasoain, I.; Pineda, O.; Edler, M. C.; Matesanz, R.; Cerezo, G.; Vanderwal, C. D.; Day, B. W.; Sorensen, E. J.; Lopez, J. A.; Andreu, J. M.; Hamel, E.; Diaz, J. F. Nat. Chem. Biol. 2007, 3, 117-125.

31. Transition States of the Retro-Ene Reactions of Allylic Diazenes

Jabbari, A.; Sorensen, E. J.; Houk, K. N. Org. Lett. 2006, 8, 3105-3107.

30. Convergent, Enantioselective Syntheses of Guanacastepenes A and E Featuring Cyclobutane Fragmentation

Shipe, W. D.; Sorensen, E. J. J. Am. Chem. Soc. 2006, 128, 7025-7035.

29. Cyclostreptin (FR182877), an Antitumor Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite its High Affinity for the Taxoid Site.

Edler, M. C.; Buey, R. M.; Gussio, R.; Marcus, A. I.; Vanderwal, C. D.; Sorensen, E. J.; Diaz, J. F.; Giannakakou, P.; Hamel, E. Biochemistry 2005, 44, 11525-11538.

28. A Diels-Alder Macrocyclization Enables an Efficient, Asymmetric Synthesis of the Antibacterial Natural Product Abyssomicin C

Zapf, C. W.; Harrison, B. A.; Drahl, C.; Sorensen, E. J. Angew. Chem. Int. Ed. 2005, 44, 6533-6537.

27. Target Discovery in Small-Molecule Cell-Based Screens by in situ Proteome Reactivity Profiling

Evans, M. J.; Saghatelian, A.; Sorensen, E. J.; Cravatt, B. F.Nature Biotech. 2005, 23, 1303-1307.

26. Protein-Reactive Natural Products

Drahl, C.; Cravatt, B. F.; Sorensen, E. J. Angew. Chem. Int. Ed. 2005, 44, 5788-5809.

25. Design, Synthesis, and Reactivity of 1-Hydrazinodienes for Use in Organic Synthesis.

Sammis, G. M.; Flamme, E. M.; Xie, H.; Ho, D. M.; Sorensen, E. J. J. Am. Chem. Soc. 2005, 127, 8612-8613.

24. Palladium-Catalyzed Ring-Forming Aminoacetoxylation of Alkenes

Alexanian, E. J.; Lee, C. B.; Sorensen, E. J. J. Am. Chem. Soc. 2005, 127, 7690-7691.

23. A Remarkable Architectural Self-Construction Process is Discovered in a Synthesis of FR182877.

Vanderwal, C. D.; Sorensen, E. J. An invited contribution to Strategies and Tactics in Organic Synthesis. M. Harmata, Ed. Academic Press: New York, 2004

22. A Dash of Proline Makes Things Sweet

Sorensen, E. J.; Sammis, G. M. Science 2004, 305, 1725-1726.

21. A Nucleophile-Catalyzed Cycloisomerization Permits a Concise Synthesis of (+)-Harziphilone.

Stark, L. M.; Pekari, K.; Sorensen, E. J. PNAS 2004, 101, 12064-12066.

20. Synthesis of the Furanosteroidal Antibiotic Viridin

Anderson, E. A.; Alexanian, E. J.; Sorensen, E. J. Angew. Chem. Int. Ed. 2004, 43, 1998-2001.

19. (-)-FR182877 is a Potent and Selective Inhibitor of Carboxylesterase-1

Adam, G. C.; Vanderwal, C. D.; Sorensen, E. J.; Cravatt, B. F. Angew. Chem. Int. Ed. 2003, 42, 5480–5484.

18. A Spontaneous Bicyclization Facilitates a Synthesis of (-)-Hispidospermidin.

Tamiya, J.; Sorensen, E. J. Tetrahedron 2003, 59, 6921-6932.

17. Architectural Self-Construction in Nature and Chemical Synthesis

Sorensen, E. J. An invited essay for Bioorganic & Medicinal Chemistry 2003, 11, 3225-3228.

16. An Enantioselective Synthesis of FR182877 Provides a Chemical Rationalization of its Structure and Affords Multigram Quantities of its Direct Precursor.

Vanderwal, C. D.; Vosburg, D. A.; Weiler, S.; Sorensen, E. J. J. Am. Chem. Soc. 2003, 125, 5393-5407.

15. Concise Stereocontrolled Routes to Fumagillol, Fumagillin, and TNP-470.

Vosburg, D. A.; Weiler, S.; Sorensen, E. J. Chirality 2003, 15, 156-166.

14. Trifunctional Chemical Probes for the Consolidated Detection and Identification of Enzyme Activities from Complex Proteomes.

Adam, G. C.; Sorensen, E. J.; Cravatt, B. F. Mol. & Cell. Proteomics 2002, 1, 828-835.

12. Proteomic Profiling of Mechanistically Distinct Enzyme Classes Using a Common Chemotype

Adam, G. C.; Sorensen, E. J.; Cravatt, B. F. Nature Biotechnology 2002, 20, 805-809.

11. A Convergent Synthesis of the Tricyclic Architecture of the Guanacastepenes Featuring a Selective Ring Fragmentation.

Shipe, W. D.; Sorensen, E. J. Org. Lett. 2002, 4, 2063-2066.

10. A Synthesis of (+)-FR182877, Featuring Tandem Transannular Diels-Alder Reactions Inspired by a Postulated Biogenesis.

Vosburg, D. A.; Vanderwal, C. D.; Sorensen, E. J. J. Am. Chem. Soc. 2002, 124, 4552-4553.

9. Intramolecular Allenolate Acylations in Studies Toward a Synthesis of FR182877

Vanderwal, C. D.; Vosburg, D. A.; Sorensen, E. J. Org. Lett. 2001, 3, 4307-4310.

8. Profiling the Specific Reactivity of the Proteome with Non-directed Activity-based Probes.

Adam, G. C.; Cravatt, B. F.; Sorensen, E. J. Chemistry & Biology 2001, 8, 81-95.

7. Chemical Strategies for the Global Analysis of Protein Function

Cravatt, B. F.; Sorensen, E. J. An invited review for Current Opinion in Chemical Biology. 2000, 4, 663-668.

6. An Enantiospecific Synthesis of the Potent Immunosuppressant FR901483

Scheffler, G.; Seike, H.; Sorensen, E. J. Angew. Chem. Int. Ed. 2000, 39, 4593-4596.

5. A Concise Synthesis of (–)-Hispidospermidin Guided by a Postulated Biogenesis

Tamiya, J.; Sorensen, E. J. J. Am. Chem. Soc. 2000, 122, 9556-9557.

4. Albert Eschenmoser

Sorensen, E. J. Helv. Chim. Acta. 2000, 83, 1673-1677.

3. Selected, Recent Developments in the Chemical Synthesis of Biologically Active Natural Products

Sorensen, E. J. An invited review for Current Opinion in Drug Discovery and Development 1999, 2, 606-630.

2. Postulated Biogenesis of WS9885B and Progress Toward an Enantioselective Synthesis

Vanderwal, C. D.; Vosburg, D. A.; Weiler, S.; Sorensen, E. J. Org. Lett. 1999, 1, 645-648.

1. A Concise Synthesis of Fumagillol

Vosburg, D. A.; Weiler, S.; Sorensen, E. J. Angew. Chem. Int. Ed. 1999, 38, 971-974.